![]() ![]() This novel synthetic route opens a new dimension of control in the synthesis of 2D metals, enabling new kinds of mesoporous architectures with abundant catalytically active sites. Mesoporous Ir nanosheets can be synthesized with close-packed assemblies of diblock copolymer (poly-(ethylene oxide)-b-polystyrene, PEO-b-PS) micelles aligned in the 2D plane of the nanosheets. Here, we report a novel synthetic strategy to prepare an unprecedented type of 2D mesoporous metallic iridium (Ir) nanosheet. Adding mesopores in the plane of ultrathin 2D metals is the next big step in manipulating these structures because increasing their surface area improves the utilization of the material and the availability of active sites. Because of their unique structural features, the mesoporous metallic Ir nanosheets exhibit a high electrocatalytic activity toward the oxygen evolution reaction (OER) in acidic solution as compared to commercially available catalysts.Ībstract = "Two-dimensional (2D) metals are an emerging class of nanostructures that have attracted enormous research interest due to their unusual electronic and thermal transport properties. Based on these results, it appears that the anticancer efficacy of these complexes was predominantly attributed to the redox mechanism.Two-dimensional (2D) metals are an emerging class of nanostructures that have attracted enormous research interest due to their unusual electronic and thermal transport properties. Additionally, the complexes were observed to induce late apoptosis and perturb the cell cycle in the G 2/M or S phase in A549 cells. The study revealed that these complexes could target mitochondria, cause depolarization of the mitochondrial membrane, and trigger the production of intracellular ROS. The charge pattern of the metal center (neutral or cationic) and ligand substituents showed little influence on the cytotoxicity and selectivity of these complexes. Unfortunately, these complexes had a low selectivity (selectivity index: 1.62–1.98) towards A549 cells and BEAS-2B normal cells. The complexes demonstrated promising cytotoxicity against lung cancer A549 cells, cisplatin-resistant lung cancer A549/DDP cells, cervical carcinoma HeLa cells and human liver carcinoma HepG2 cells, with IC 50 values ranging from 9.98 to 19.63 μM. They were stable in aqueous media, displayed moderate fluorescence and exhibited affinity toward bovine serum albumin (BSA). The cyclometalated iridium( III) complexes were identified by various techniques. We herein synthesized a series of neutral and cationic amine–imine cyclometalated iridium( III) complexes using Schiff base ligands with sp 2-N/sp 3-N N^NH 2 chelating donors. Most platinum group-based cyclometalated neutral and cationic anticancer complexes with the general formula 0/+ (neutral complex: XY = bidentate anionic ligand cationic complex: XY = bidentate neutral ligand) are notable owing to their intrinsic luminescence properties, good cell permeability, interaction with some biomolecular targets and unique mechanisms of action (MoAs). ![]()
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